Technology

Juvéderm · Restylane · Belotero · Revanesse

Juvéderm, Restylane, Belotero and Revanesse are dermal fillers made from cross-linked hyaluronic acid, a water-binding substance found naturally in the body.

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The essentials

Understanding Juvéderm · Restylane · Belotero · Revanesse.

Juvéderm, Restylane, Belotero and Revanesse are families of injectable dermal fillers based on hyaluronic acid, a sugar-based molecule that occurs naturally in skin and other tissues and has a strong capacity to bind water. In its natural form hyaluronic acid breaks down quickly, so in these products it is chemically modified and linked together (cross-linked) into a stable gel that persists longer after injection. Each brand offers a range of gels with different thicknesses and flow characteristics, which are designed for different tissue depths and purposes, from fine lines to deeper volume support. They are injected by one of our physicians: Dr. Gidon Frame, Dr. Sarina Govindasamy, or Dr. Teri Fisher.

How do dermal fillers work?

Once placed in the skin or deeper tissue, the cross-linked hyaluronic acid gel adds volume directly by occupying space and by attracting and holding water, which can lift, contour or smooth the treated area. Because the gel is similar to the body's own hyaluronic acid, it is gradually broken down over time by natural processes, which is why the effect is temporary. The specific gel chosen matters: firmer gels are generally used deeper to give structural fullness, while softer gels are placed more superficially to address fine lines, and the choice is matched to the goal and the area.

Where it's used

Hyaluronic acid fillers are commonly used to restore volume that diminishes with age, to contour or define certain facial areas, and to soften folds and lines that are due to volume loss rather than muscle movement; lip enhancement and hydration are also common uses. Some products are also used for hand rejuvenation. The specific facial and body areas that are formally authorized differ by product and gel type, and some uses a clinician may discuss are considered off-label. Fillers address volume and contour, not lines caused purely by muscle movement, and are not a treatment for skin quality or pigmentation concerns, so they are not appropriate for every goal.

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What to expect from it

These fillers can provide a relatively immediate change in volume or contour through an in-office procedure, and for most people involve limited downtime. A meaningful practical characteristic of hyaluronic acid fillers is that, unlike some other filler types, they can often be broken down with an enzyme (hyaluronidase) if adjustment is needed or in the event of a complication, which offers a degree of reversibility. The effect is temporary and gradually fades, so maintenance treatments are needed to sustain a result. Outcomes depend on the product, the area, the volume used and the injector's technique, and results are not guaranteed.

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Safety profile and limits

Dermal fillers are medical products that should be injected only by appropriately trained clinicians after assessment. Common, usually temporary effects include swelling, redness, bruising, tenderness and firmness at the injection site. Less common risks include lumps or nodules, asymmetry, infection and allergic reaction. A rare but serious risk is accidental injection into or compression of a blood vessel, which can block blood flow and, very rarely, damage skin or affect vision; this requires urgent medical attention. Fillers are generally avoided where there is active infection at the site, certain medical conditions or known allergy to a component, and their use in pregnancy and breastfeeding is generally not advised. A physician-led consultation is needed to confirm suitability, choose the appropriate product and discuss risks.

Discuss Vascular Risk With the Physician Who Would Inject You →

Conditions It May Help Address

Concerns connected to this technology.

The relationship between a technology and a concern depends on the treatment plan, patient assessment, and how the technology is being used.

Loose or Crepey Skin

Reduced firmness and mild tissue descent related to aging and the decline of collagen and elastin.

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Thin or Uneven Lips

Lips with reduced fullness, shape, projection, or border definition, sometimes with mild asymmetry.

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Gummy Smile

A smile that shows more upper gum tissue than a person would prefer.

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Penile Girth Concerns

Concerns about penile girth, circumference or proportion — sometimes searched as penis enlargement or male enhancement — whether from perception, natural variation, or a change after injury or treatment.

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FAQ

Questions about Juvéderm · Restylane · Belotero · Revanesse.

Hyaluronic acid is a water-binding molecule that occurs naturally in skin and other tissues. In these fillers it is modified and cross-linked into a stable gel so that it lasts longer after injection than the body's own hyaluronic acid, which breaks down quickly. The gel is gradually broken down over time by natural processes.

The effect is temporary and gradually fades as the gel is broken down naturally, so maintenance treatments are needed to sustain a result. How long it lasts varies with the product, the area treated, the amount used and the individual. Your physician can give you a more specific expectation for your situation.

One practical feature of hyaluronic acid fillers is that they can often be broken down with an enzyme called hyaluronidase if an adjustment is needed or if a complication occurs. This offers a degree of reversibility, though the decision and the outcome depend on the specific situation. It is managed by the physician treating you: Dr. Gidon Frame, Dr. Sarina Govindasamy, or Dr. Teri Fisher.

Fillers add volume or support to areas affected by volume loss or to smooth certain folds, whereas botulinum toxin temporarily relaxes muscles to soften lines caused by movement. They address different concerns and are sometimes used together. A clinical assessment can clarify which, if either, suits your goals.

Most effects are mild and temporary, such as swelling or bruising. A rare but serious risk is accidental injection into or compression of a blood vessel, which can affect blood flow and, very rarely, the skin or vision. Being treated by a physician who knows facial anatomy, and discussing risks before treatment, are important parts of reducing and managing that risk.

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Medical Review

Reviewed for clinical accuracy.

Medically reviewed by Dr. Gidon Frame, Medical Director, Anti-Aging Medical & Laser Clinic (CPSBC).
Last medically reviewed: August 2026.
Evidence reviewed: clinical practice guidelines, systematic reviews and peer-reviewed medical literature.

AuthorDr. Gidon Frame
Medical ReviewerDr. Gidon Frame
Last ReviewedAugust 2026
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